Nakon 162 odigrane utakmice završena je regularna sezona i poznati su šampioni divizija i ostali učesnici MLB plejofa.
Što se Američke lige tiče, šampioni divizija su Baltimor Oriols (Istok), Minesota Tvins (Centar) i Hjuston Astros (Zapad), dok su pored njih plasman u plejof obezbedili i Toronto Blue Džejs, Teksas Rendžers i Tampa Bej Rejs. Baltimor i Hjuston su se plasirali direktno u ALDS, dok će ostale ekipe da igraju wild card seriju.
U Nacionalnoj ligi šampioni divizija su Atlanta Brejvs (Istok), Milvoki Bruers (Centar) i Los Anđeles Dodžers (Zapad), dok su plejof mesto izborili i Filadelfija Filis, Majami Marlins i Arizona Dajmondbeks. Atlanta i LA Dodžersi su direktni učesnici NLDS-a.
World Series
| Датум | Utakmica | Poč/Rez | Stadion |
|---|---|---|---|
| Rangers - D-Backs | 6 - 5 | Globe Life Field | |
| Rangers - D-Backs | 1 - 9 | Globe Life Field | |
| D-Backs - Rangers | 1 - 3 | Chase Field | |
| D-Backs - Rangers | 7 - 11 | Chase Field | |
| D-Backs - Rangers | 0 - 5 | Chase Field |
Američka liga - šampionatska serija (ALCS)
| Датум | Utakmica | Poč/Rez | Stadion |
|---|---|---|---|
| Astros - Rangers | 0 - 2 | Minute Maid Park | |
| Astros - Rangers | 4 - 5 | Minute Maid Park | |
| Rangers - Astros | 5 - 8 | Globe Life Field | |
| Rangers - Astros | 3 - 10 | Globe Life Field | |
| Rangers - Astros | 4 - 5 | Globe Life Field | |
| Astros - Rangers | 2 - 9 | Minute Maid Park | |
| Astros - Rangers | 4 - 11 | Minute Maid Park |
Nacionalna liga - šampionatska serija (NLCS)
| Датум | Utakmica | Poč/Rez | Stadion |
|---|---|---|---|
| Phillies - D-Backs | 5 - 3 | Citizens Bank Park | |
| Phillies - D-Backs | 10 - 0 | Citizens Bank Park | |
| D-Backs - Phillies | 2 - 1 | Chase Field | |
| D-Backs - Phillies | 6 - 5 | Chase Field | |
| D-Backs - Phillies | 1 - 6 | Chase Field | |
| Phillies - D-Backs | 1 - 5 | Citizens Bank Park | |
| Phillies - D-Backs | 2 - 4 | Citizens Bank Park |
Američka liga - divizijske serije (ALDS)
| Датум | Utakmica | Poč/Rez | Stadion |
|---|---|---|---|
| Orioles - Rangers | 2 - 3 | Oriole Park at Camden Yards | |
| Astros - Twins | 6 - 4 | Minute Maid Park | |
| Orioles - Rangers | 8 - 11 | Oriole Park at Camden Yards | |
| Astros - Twins | 2 - 6 | Minute Maid Park | |
| Twins - Astros | 1 - 9 | Target Field | |
| Rangers - Orioles | 7 - 1 | Globe Life Field | |
| Twins - Astros | 2 - 3 | Target Field |
Nacionalna liga - divizijske serije (NLDS)
| Датум | Utakmica | Poč/Rez | Stadion |
|---|---|---|---|
| Braves - Phillies | 0 - 3 | Truist Park | |
| Dodgers - D-Backs | 2 - 11 | Dodger Stadium | |
| Braves - Phillies | 5 - 4 | Truist Park | |
| Dodgers - D-Backs | 2 - 4 | Dodger Stadium | |
| Phillies - Braves | 10 - 2 | Citizens Bank Park | |
| D-Backs - Dodgers | 4 - 2 | Chase Field | |
| Phillies - Braves | 3 - 1 | Citizens Bank Park |
Američka liga - Wild Card
| Датум | Utakmica | Poč/Rez | Stadion |
|---|---|---|---|
| Rays - Rangers | 0 - 4 | Tropicana Field | |
| Twins - Blue Jays | 3 - 1 | Target Field | |
| Rays - Rangers | 1 - 7 | Tropicana Field | |
| Twins - Blue Jays | 2 - 0 | Target Field |
Nacionalna liga - Wild Card
| Датум | Utakmica | Poč/Rez | Stadion |
|---|---|---|---|
| Brewers - D-Backs | 3 - 6 | American Family Field | |
| Phillies - Marlins | 4 - 1 | Citizens Bank Park | |
| Brewers - D-Backs | 2 - 5 | American Family Field | |
| Phillies - Marlins | 7 - 1 | Citizens Bank Park |