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40-man roster
| 81 | Jordan Balazovic | P |
| 25 | Byron Buxton | DH |
| 50 | Willi Castro | LF |
| 21 | Gilberto Celestino | CF |
| 4 | Carlos Correa | SS |
| 59 | Jhoan Duran | P |
| 12 | Kyle Farmer | 3B |
| 55 | Kody Funderburk | P |
| 13 | Joey Gallo | LF |
| 54 | Sonny Gray | P |
| 53 | Brent Headrick | P |
| 31 | Ronny Henriquez | P |
| 22 | Griffin Jax | P |
| 27 | Ryan Jeffers | C |
| 47 | Edouard Julien | 2B |
| 26 | Max Kepler | RF |
| 60 | Dallas Keuchel | P |
| 19 | Alex Kirilloff | 1B |
| 9 | Trevor Larnach | LF |
| 23 | Royce Lewis | 3B |
| 49 | Pablo Lopez | P |
| 16 | Jordan Luplow | LF |
| 18 | Kenta Maeda | P |
| 17 | Bailey Ober | P |
| 20 | Chris Paddack | P |
| 15 | Emilio Pagan | P |
| 11 | Jorge Polanco | 2B |
| 41 | Joe Ryan | P |
| 77 | Cole Sands | P |
| 39 | Donovan Solano | 1B |
| 45 | Andrew Stevenson | CF |
| 61 | Brock Stewart | P |
| 2 | Michael A. Taylor | CF |
| 56 | Caleb Thielbar | P |
| 37 | Louie Varland | P |
| 8 | Christian Vazquez | C |
| 38 | Matt Wallner | RF |
| 74 | Josh Winder | P |
| 78 | Simeon Woods Richardson | P |
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